{"id":1007,"date":"2020-12-03T10:51:17","date_gmt":"2020-12-03T01:51:17","guid":{"rendered":"https:\/\/www.promega.co.jp\/resources\/faq\/?p=1007"},"modified":"2021-01-27T16:54:12","modified_gmt":"2021-01-27T07:54:12","slug":"q751","status":"publish","type":"post","link":"https:\/\/www.promega.co.jp\/resources\/faq\/cell-health\/adme\/p450\/p450-glo\/q751","title":{"rendered":"\u7d30\u80de\u3092\u85ac\u5264\u3067\u523a\u6fc0\u3057\u3066CYP450\u3092\u8a98\u5c0e\u3055\u305b\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u3059\u304b\uff1f"},"content":{"rendered":"\n<p>P450-Glo\u2122\u3092\u7528\u3044\u3066\u3001rifampicin\u306a\u3069\u306e\u8a98\u5c0e\u5264\u306b\u3088\u308bCYP450\u767a\u73fe\u8a98\u5c0e\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u88683\u306f\u8a98\u5c0e\u30a2\u30c3\u30bb\u30a4\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308bCYP450\u5206\u5b50\u7a2e\u3068\u3001\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u8a98\u5c0e\u5264\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u88683\u3000\u4e00\u822c\u7684\u306aCYP450\u8a98\u5c0e\u5264<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th><strong>CYP450\u5206\u5b50<\/strong><\/th><th><strong>\u8a98\u5c0e\u5264<\/strong><\/th><th><strong>\u6fc3\u5ea6<\/strong><\/th><th><strong>Pathway<\/strong><\/th><\/tr><tr><td>CYP3A4<\/td><td><strong>rifampicin<\/strong><br><strong>phenobarbitol<\/strong><br><strong>dexamethasone<\/strong><\/td><td>25 \u03bcM<br>500 \u03bcM<br>50 \u03bcM<\/td><td>PXR<br>CAR<br>GR<\/td><\/tr><tr><td>CYP2C9<\/td><td><strong>rifampicin<\/strong><br><strong>phenobarbitol<\/strong><\/td><td>25 \u03bcM<br>500 \u03bcM<\/td><td>PXR\/CAR<\/td><\/tr><tr><td>CYP1A1\/1A2\/1B1<\/td><td><strong>2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)<\/strong><br><strong>3-methylcholanthrene<\/strong><br><strong>omeprazole<\/strong><\/td><td>10 nM<br>1 \u03bcM<br>100 \u03bcM<\/td><td>AHR<\/td><\/tr><tr><td>CYP2B6<\/td><td><strong>phenobarbitol<\/strong><\/td><td>1 mM<\/td><td>CAR<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>CYP450 \u8a98\u5c0e\u306e\u8a73\u7d30\u306a\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/www.promega.jp\/Resources\/Protocols\/Technical%20Bulletins\/101\/P450%20Glo%20Assays%20Protocol\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u88fd\u54c1\u30de\u30cb\u30e5\u30a2\u30eb<\/a>\u3001\u30bb\u30af\u30b7\u30e7\u30f311\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P450-Glo\u2122\u3092\u7528\u3044\u3066\u3001rifampicin\u306a\u3069\u306e\u8a98\u5c0e\u5264\u306b\u3088\u308bCYP450\u767a\u73fe\u8a98\u5c0e\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u88683\u306f\u8a98\u5c0e\u30a2\u30c3\u30bb\u30a4\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308bCYP450\u5206\u5b50\u7a2e\u3068\u3001\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u8a98\u5c0e\u5264\u306e\u7d44\u307f &#8230; <\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[235],"tags":[],"_links":{"self":[{"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/posts\/1007"}],"collection":[{"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/comments?post=1007"}],"version-history":[{"count":2,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/posts\/1007\/revisions"}],"predecessor-version":[{"id":2463,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/posts\/1007\/revisions\/2463"}],"wp:attachment":[{"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/media?parent=1007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/categories?post=1007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.promega.co.jp\/resources\/faq\/wp-json\/wp\/v2\/tags?post=1007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}